Deterministic Mathematical Model and Analysis of Transmission Dynamics of Covid-19 from Reservoir-to-Human

Authors

DOI:

https://doi.org/10.5540/tcam.2025.026.e01796

Keywords:

Asymptotic Stability, Covid-19, Deterministic, Dynamics, Reservoir-to-Human

Abstract

This article presents a deterministic mathematical model for the transmission dynamics of covid-19 from the reservoir to the people was formulated. The model system properties was analysed such as feasibility of the solutions, positivity of the state variables,
stability of the model equilibria both local and global equilibria points. Also, the basic reproduction number R0 was computed along its sensitivity for model parameters to identify the most persuading parameter and the results proved that high values of the parameters associated with the rate of controlling the infection out of human life back to reservoir will drastically
minimized the spread rate of Covid-19 in people. The local stability of disease-free equilibrium was determined through the trace and determinant of matrix method. The disease-free equilibrium will be asymptotically stable if the tr(J+) < 0 and det(J+) > 0. The disease-free
and endemic equilibria was found to be globally stable when the R0 < 1 and R0 > 1 respectively. The analysis of the numerial simulation the model on various sets of parameters displayed that there is a strong noteworthy effect on the virulent if the efort of controlling the infection is at the rate of not less than 50% to pull back the infection out of people to reservoir or vanishing.

Author Biography

A. J. Akingbade, University of Ilorin, Ilorin Kwara State, Nigeria

Department of Mathematice and Ph.D Students

References

W. H. Organization, "Coronavirus disease 2019 (covid-19)," Situation report.

S. P. Adhikari, S. Meng, Y. J. Wu, Y. P. Mao, R. X. Ye, Q. Z. Wang, C. Sun, S. Sylvia,S. Rozelle, H. Raat, and H. Zhou, "Epidemiology, causes, clinical manifestation and diagnosis, prevention and control of coronavirus disease (covid-19) during the early outbreak period, "A Scoping Review. Infectious Diseases of Poverty, vol. 9, no. 29, 2020.

Q. Li, X. Guan, and P. Wu, "Early transmission dynamics in wuhan, china, of novel coronavirus-infected pneumonia," N Engl J Med., vol. 382(13), 2020.

WHO, "Novel coronavirusjapan (ex-china),"

"Covid-19," accessed date: June 4, 2020.

G. W. J and N. H. etal, Clinic al characteristics of coronavirus disease in 2019 in china journal N EngJ Med.2020, volume = 382, page 1708-20, year 2019,

K. G. Andersen, A. Rambaut, W. I. Lipkin, E. C. Holmes, and G. R. F., The proximal origin of sars-cov-2., Nat Med., vol. 26, (2020), page = 450452.

J. F. Chan, K. H. Kok, Z. Zhu, H. Chu, K. K. To, and Y. S. et al, Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical

pneumonia after visiting wuhan, Emerg Microbes Infect., vol. 9, p. 221-236, 2020.

M. letko, A. Marz, and V. Munster, functional assessment of cell entry and receptor usage for stars-cov-2 and other lineage b beta corona viruses, Nat Mircobiol., vol. 5:52-59, 2020.

K. S. Akhil, N. Stollenwerk, and M. Aguiar, deterministic and stochastic dynamics of covid-19: The case study of italy and spain, Computational and Mathematical Methods, vol. Article ID 5780719, 16 pages, 2022.

A. Amirudh journal of homepage: www.kae publishing. lonlinding, infectiuos disease modeling, vol. 5, pp. 366 -374, (2020).

A. Atangana and S. I. Araz, A mathematical model with covid-19 reservoir. in fractional stochastic differential equations: Applications to covid-19 modeling, Singapore: Springer Nature Singapore, vol. 423-480, 2022.

J. Bakshi, S. S. Ayon, and M. H. A. Biswas, Mathematical modeling of reservoir-mediatorhuman dynamical transmission of covid-19 outbreak, In 11th Annual International Conference on Industrial Engineering and Operations Management, IEOM, vol. 875-886, 2021.

E. A. Hernandez-Vargas and J. X. Velasco-Hernandez, In-host mathematical modelling of covid-19 in humans, Annual reviews in control, vol. 50, 2020.

D. J. E. A. Jose and N. O. Jose, Global analysis of the covid-19 pandemic using simple epidemiological models," 2020 arXiv preprint arXiv:2005.06742.

W. K. Ming, J. Huang, and C. J. Zhang, "Breaking down of healthcare system: Mathematical modelling for controlling the novel coronavirus (2019-ncov) outbreak in wuhan, china," BioRxiv, 2020.

P. M. I. R. M. S. W. A., Suwardi and S. S., "Stability analysis and numerical simulation of seir model for pandemic covid-19 spread in indonesia," Chaos, Solit. Fractals, 2020.

H. M. N. H., Tuan and R. S., "A mathematical model for covid-19 transmission by using the caputo fractional derivative. journal Chaos, Solitons & Fractals, volume 140, 110107, year 2020,

W. O. Kermack and A. G. McKendrick, "contribution to the mathematical theory of epidemics" Proc. Royal Soc. London,, vol. 15(772), pp. 700 - 721, (1927).

B. G. and R. G. C., Ordinary differential equations, fourth edition. John Wiley and Sons,4th ed., (1989).

D. O. and H. J. A. . P, Mathematical epidemiology of infectious diseases, vol. (Vol. 5). John Wiley and Sons, (2000).

P. Van den Driessche and J. Watmough, "Reproduction numbers and sub-threshold endemic equilibria for compartmental models of disease transmission.," Mathematical Biosciences,,vol. 180(1-2), pp. 29 - 48, (2002).

J. A. Akingbade, R. A. Adetona, and B. S. Ogundare, "Mathematical model for the study of transmission and control of measles with immunity at initial stage.," Malaya Journal of Mathematik,, vol. vol.6, no. No. 4, pp. 823834, (2018).

S. Nana-Kyere, K. H. Glory, E. Okyere, N. Seth, J. K. A. Marmah, and D. V. Obuobi, "A qualitative analysis of neisseria gonorrhea disease with treatment effect," Applied Mathematics, vol. 6(1), 2016.

C. Vargas-De-LeAon, "Constructions of lyapunov functions for classic sis, sir and sirs epidemic models with variable population size," Foro-Red-Mat: Revista Electr'onica de Contenido Matem 'atico, vol. 26, pp. 1 - 12., (2009).

C. Vargas-De-LeAon, "Stability analysis of a sis epidemic model with standard incidence," Foro-Red-Mat: Revista Electr'onica de Contenido Matem'atico, vol. 28, no. 4, pp. 1 - 11, (2011).

P. Adda and D. Bichara, Global stability for s,i,r and s,i,r,s models with differential mortality, vol. 1 - 17, no. 8(8), 2011.

J. A. Akingbade and B. S. Ogundare, "boundedness and stability properties of solutions of mathematical model of measles", Tamkang Journal of Mathematics, vol. Vol. 52, no. No. 1, pp. pp.91-112, 2021.

N. P. Bhatia and G. P. Szego, Stability theory of dynamical systems. Springer, Berlin, 1970.

K. A. and W. G. C., "Lyapunov functions and global stability for sir, sirs, and sis epidemiological models," Appl. Math. Lett.,, vol. 15, no. (8), pp. 955 - 960., (2002).

K. A. and M. P., "Lyapunov functions and global properties for seir and seis models.," Math.Med. Biol., vol. 21, pp. 75 - 83., (2004a).

K. A. and M. P., A lyapunov function and global properties for s - i - r and seir epidemiological models with nonlinear incidence, Mathematical Biosciences and Engineering,, vol. 1, pp. 57 - 60., June (2004b).

N. H. J. M. Chitnis and C. J. M., Determining important parameters in the spread of malaria through the sensitivity analysis of a mathematical model., Bulletin of Mathematical Biology, vol. 70(5), p. 1272, 22 February (2008).

Downloads

Published

2025-04-17

How to Cite

Akingbade, A. J. (2025). Deterministic Mathematical Model and Analysis of Transmission Dynamics of Covid-19 from Reservoir-to-Human. Trends in Computational and Applied Mathematics, 26(1), e01796. https://doi.org/10.5540/tcam.2025.026.e01796

Issue

Section

Original Article