Explorando Longo Período de Interação entre Sistema Imunológico e HIV
DOI:
https://doi.org/10.5540/tema.2010.011.02.0159Abstract
O Vírus da Imunodeficiência Humana (HIV), infectando células TCD4 +, consegue comprometer gravemente o funcionamento do Sistema Imunológico, resultando em AIDS. Formulamos e analisamos três modelos matemáticos para este processo de infecção. Foi possível encontrar um limiar para a permanência do vírus na corrente sanguínea e evidenciar a necessidade da apoptose de células ativadas, após a eliminação do antígeno. Através da introdução de um termo de exaustão cumulativa (resultado da constante tentativa do sistema imunológico responder à infecção pelo HIV) também reproduzimos a diminuição do número de células T-CD4+ ao longo dos anos.References
[1] A.K. Abbas, “Imunologia Celular e Molecular”, Elsevier, Rio de Janeiro, 2005.
[2] F. Barré-Sinoussi et al. Isolation of a T-lymphotropic retrovírus from a patient at risk for acquired immune deficiency syndrome (AIDS). Science, 220 (1983), 868–871.
[3] S. Barrozo, H.M. Yang, Mecanismos da iteração antígeno-anticorpo em uma resposta primária célula T-mediada, Tend. Mat. Apl. Comput., 7, No.1 (2006)43–52.
[4] S. Barrozo, H.M. Yang, Desenvolvimento de um modelo para resposta imunológica primária célula-mediada, Tend. Mat. Apl. Comput., 7, No.1 (2006) 31–41.
[5] P.F. Bonolo et al. Adesão à terapia anti-retroviral (HIV/aids): fatores associados e medidas da adesão, Epidemiol. Serv. Saúde 16 (2007), 251–259.
[6] R.C. Gallo, P.S. Sarin, E.P. Gelmann et al. Isolation of human T-cell leukemia virus in acquired immunodeficiency syndrome (Aids). Science, 220 (1983), 865–867.
[7] A. Hughes, T. Barber, M. Nelson, New treatment options for HIV salvage patients: An overview of second generation Pis, NNRTIs, integrase innibitors and CCR5 antagonists. J. Infect, London, 57 (2008), 1–10.
[8] C.A. Janeway Jr., How the immune system reconizes invaders. Scientific American, 269 (1993), 73–79.
[9] H. Kim, A.S. Perelson, Viral and Latent Reservoir Persistence in HIV-1-Infected Patients on Therapy, PLoS Cumput. Biol. 2 (2006), 1232–1247.
[10] M. Oprea, A.S. Perelson, Exploring the mechanisms of primary antibory responses to T-cell dependent antigens, J. Theor. Biol., 181 (1996), 215–236.
[11] A.S. Perelson, P.W. Nelson, Mathematical analysis of HIV-I dynamics in vivo, Society for Industrial and Applied Mathematics, 41 (1999), 3–44
[12] R.J. Smith, B.D. Aggarwala, Can the viral reservoir of latently infected CD4+ T cells be eradicated with antiretroviral HIV drugs?, J. Math. Biol., 59 (2009), 697–715.
[13] R.J. Smith, Explicitly accounting for antiretroviral drug uptake in theoretical HIV models predicts long-term failure of protease-onli therapy Journal of Theoretical Biology, 251 (2008), 227–237.
[14] L. Sompayrac, “How Pathogenic Vírus Work”, Jones and Bartlett Publishers, Massachusetts, 2002.
Downloads
Published
How to Cite
Issue
Section
License
Authors who publish in this journal agree to the following terms:
Authors retain copyright and grant the journal the right of first publication, with the work simultaneously licensed under the Creative Commons Attribution License that allows the sharing of the work with acknowledgment of authorship and initial publication in this journal.
Authors are authorized to assume additional contracts separately, for non-exclusive distribution of the version of the work published in this journal (eg, publish in an institutional repository or as a book chapter), with acknowledgment of authorship and initial publication in this journal.
Authors are allowed and encouraged to publish and distribute their work online (eg, in institutional repositories or on their personal page) at any point before or during the editorial process, as this can generate productive changes as well as increase impact and the citation of the published work (See The effect of open access).
This is an open access journal which means that all content is freely available without charge to the user or his/her institution. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the
author. This is in accordance with the BOAI definition of open access
Intellectual Property
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License under attribution BY.